We would like to invite you to the EASL Monothematic Conference on "CHOLANGIOCYTES IN HEALTH AND DISEASE: FROM BASIC SCIENCE TO NOVEL TREATMENTS" to be held on 09-11 June 2017 in Oslo, Norway.
|Covered topics - Biliary tree, anatomy and 3D structure, bioengineering, cholangiocyte pathophysiology, immunity, genetics, carcinogenesis, cholangiocarcinoma, clinical practice, biomarkers, diseases management.|
Bioengineers and physicists are linking up with biologists, translational scientists and clinicians to get a better understanding of the complexity of the many acquired and genetic cholestatic liver diseases. Novel genetic information, multimodal imaging, pathway analysis, digitalized microscopy and reconstructions and novel mouse models shed a new light on the relation between anatomy and function in the liver in general and in the biliary tree in particular. Intravital 2-photon microscopy makes us aware of the dynamics and function of cholangiocytes, bile canaliculi and bile ducts. Metabolomic analysis point to hitherto hidden spatio-temporal relations and disturbances that play an underestimated role in the developmental phases of cholestatic liver disease.
The discovery of nuclear hormone receptors and signaling paths, involved in the regulation of gene expression, give rise to new drugs that suppress disease activity and in the long run may be able to cure these diseases. An interesting side effect of these developments is the awareness among researchers and translational scientists that there are remarkable parallels between cholestatic and metabolic liver disease. Many new drugs, in trial for traditional cholestatic liver diseases, are also under investigation for the treatment of non-alcoholic steatohepatitis. These diseases may have more in common than traditional teaching tells us.
Cholangiocytes not only have a barrier function, separating toxic bile from cells and structures in and around the bile ducts, but these cells are metabolically highly active and secrete copious amounts of water, electrolytes and bicarbonate. In addition, bile ducts harbor stem cells that are important for restoration and regeneration of the entire liver. Bile duct proliferation may play an as yet incompletely understood role in epithelial mesenchymal transition and liver fibrosis. Disturbances of any of these structures and functions may lead to disease manifestations and may underlie cholestatic liver disease.
Immunology and metabolism for long have been antipodes in the cause-and-effect discussion. Now it becomes more and more clear that immunological and toxic injury are closely related and amplify each other. New thinking is required that covers both fields. Although cholangiocytes reside deep in the liver, functionally these cells are at the cross roads between environment and self. Bacterial products from the gut are absorbed, secreted in bile where they affect cholangiocytes. Recent discoveries have led to insights and a better understanding of the close interaction between cholangiocytes and gut.
Hepatology for a long time has been very much hepatocyte-oriented. Time has come to shift gears and focus on liver cells that, more than hepatocytes, have roles to play in inflammation, fibrosis, proliferation and regeneration.
We believe that going to a conference is part of one’s scientific life. You not only go there to listen to top-researchers and get new ideas but also to contribute and interact. We hope that during this conference we create an atmosphere that leads to lasting interactions above all to new and exciting science.
As organizing committee we welcome you to this EASL monothematic conference on ‘Cholangiocytes in Health and Disease: From Basic Science to Novel Treatment’.
- Basic and Translational Scientists
- Clinical researchers
- Young researchers and trainees
- Health professionals
- 3 days of cutting edge clinical and basic research on cholangiocytes
- Latest advances in biliary disorders management
- Gather and network with renowned specialists